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Intestinal Permeability"Leaky Gut" Assessment

Intestinal Permeability Assessment is a powerful noninvasive gastrointestinal test assessment of small intestinal absorption and barrier function in the bowel. The small intestine uniquely functions as a digestive/absorption organ for nutrients as well as a powerful immune and mechanical barrier against excessive absorption of bacteria, food antigens, yeast, , and other large molecules. Both absorption and increased permeability (leaky gut) are associated with chronic gastrointestinal imbalances as well as any systemic disorders.

Increased intestinal permeability (leaky gut) of the small intestine can:

Increase the number of foreign compounds entering the bloodstream

Allow bacterial antigens capable of cross-reacting with host tissue to enter the bloodstream, leading to autoimmune disease

Enhance the uptake of toxic compounds that can overwhelm the hepatic detoxification  system and lead to assist in the detoxification of antigens flooding the system

Leaky gut has been observed in a range of disorders such as:

Inflammatory Bowel Disease (IBD)

Food Allergy

Inflammatory joint disease

Chronic dermatological conditis

Studies have demonstrated that the increased intestinal permeability observed in patients with ankylosing spondylitis,, rheumatoid arthritis, and vasculitis may be important in the pathogenesis of these conditions.

Deceased permeability, on the other hand, appears as a fundamental cause of malabsorption, subsequent malnutrition, and failure to thrive. In certain disease states of the small intestine, such as gluten-sensitive enteropathy, permeability to large molecules may increase while permeability to small molecules decreases –  as a result of damage to the microvilli. As a result, nutrients become even less available tom assist in the detoxification of antigens flooding the system.

Possible cause of increased intestinal permeability (leaky gut) include:

Intestinal infection

Ingestion of allergic foods or toxic chemical

Deficient secretory IgA

Trauma and endotoxemia

The Intestinal Permeability assessment gastrointestinal test directly measures the ability of two non-metabolized sugars molecules to permeate the intestinal mucosa. The patient drinks a premeasured amount of lactulose and mannitol. The degree of intestinal permeability or malabsorption is reflected in the levels of the two sugars recovered in a urine sample collected over the next 6 hours.

This service is provided through Hoffman Clinic for Optimal Health.To schedule a consultation to see if the Intestinal Permeability Assessment can help determine the cause of your problem(s), call 813-985-1322 for an appointment.

01/16/3015. Kelly Miller DC NMD FASA FBAARM CFDMP*, physician at Hoffman Clinic for Optimal Health.

*There is currently no licensure for Naturopathic Physicians (NMD) in the state of Florida and the Florida Board of Chiropractic Medicine does not currently recognize the credentialing of the  Fellowship from the Brazil-American Academy for Aging and Regenerative Medicine (FBAARM), or the Certification in Functional Diagnostic Medicine (CFDMP) from Functional Medicine University.