WEIGHT MANAGEMENT GENETIC TESTING – Take the guesswork out of finding an effective diet and exercise solution by revealing the secret steps to achieve weight goals unlocked by your specific genetics. The test will determine whether a low fat, low carbohydrate. or balanced fat, protein, carbohydrate diet may be best for you, and whether you need mild to moderate or vigorous exercise to most efficiently lose existing body fat. The test provides new information way beyond traditional assessments to help understand the genetic factors that lead to weight gain, so that you can tailor your nutritional intake and fitness routine for improved, sustainable results.
NUTRITIONAL NEEDS GENETIC TESTING – Identify variations in your genes crucial to your B vitamin metabolism and the ability to manage oxidative stress. B vitamins are involved in every metabolic process in your body. Individuals that show suboptimal results for the genes can be at increased risk for ineffective utilization of B vitamins and potential for cell damage caused by oxidative stress, both of which can in some cases lead to increased risk for certain diseases and cancer.
HEART HEALTH GENETIC TESTING – Identify your genetic predisposition to heart attack based on inflammation. The genetic analysis identifies individuals with a lifelong tendency to produce certain chemicals in the body that lead to inflammation. Overproduction of these chemicals can start a chain reaction that ultimately may lead to a heart attack. Knowing your genetic risk will enable you to take specific actions to decrease your overall risk.
BONE HEALTH GENETIC TESTING – Identify whether you are more likely to be susceptible to spine fractures and low bone density associated with osteoporosis. Early intervention now can help prevent osteoporosis later. Preventative measures can reduce the risk of bone loss and fractures, which in the case of vertebral fractures may lead to a hunched appearance and permanent disabilities.
GENETIC TESTING FOR WEIGHT MANAGEMENT
Would you like to improve your weight loss program by 2.5X, and keep the weight off permanently? Genetic testing developed by Stanford University may provide the allusive solution to effective and permanent weight loss so many of us have been looking for. Genetic testing is able to determine an individual’s variants or polymorphisms that influence weight gain. For example, there is a variant that causes that person to absorb more fat than usual. This individual would definitely benefit from a lower fat diet. However, there are other individuals that require more than 13% of total caloric intake from monosaturated fats such as olive oil to prevent overweight/obesity. There are five variants that have been identified in four different genes. These variants help explain why the same diet can have the exact opposite effects on two different people, one losing weight and the other gaining weight. These variants also demonstrate why one person can seemingly eat anything they want and not exercise and not gain weight (fast metabolizers) and others can seemingly eat very little food and exercise regularly and not lose a pound (slow metabolizers).
Genetic testing can help determine what we should eat, what we should not eat, and the in what proportion our carbohydrate, protein, and fat ratios should be for optimum weight management. These ratios are in different proportion according to genotype. The genetic testing can also tell an individual what kind of exercise, and the intensity of exercise that they will benefit from the most for weight management. This is so important because there is actually a gene variant that will cause men to gain body fat if they do heavy weight lifting!
There are three other areas where genetic testing can provide invaluable information. The first is nutritional needs. Genetic testing can determine if an individual has an absorption, utilization, or metabolizing problem with Vitamins B, C, D, E, and more! A Vitamin B is involved in every metabolic process in the body. This information can be life-saving as some individuals will need to supplement certain B vitamins as much as 700% more than average to have normal function. The second additional area that genetic testing provides insight is in heart health. Heart disease accounts for 40% of all deaths in the United States. Certain variants will predispose an individual to greater risks. More importantly, the genetic testing provides the information on how not to express this variant. The study of the expression of genes is known as epigenetics. The third additional area that genetic testing shines is in bone health. There are three variants that increase an individual’s risk for developing osteoporosis; one involving interleukin, the second, estrogen and the third vitamin D. We will discuss more about each of these areas of genetic testing later.
All this information came about because of The Human Genome Project. The purpose of this project was to determine the human genome and to identify the genes it contains. This was an international endeavor initiated by the National Institute of Health and U.S. Department of Energy. Additional contributors included universities across the U. S and international partners in the U.K., France, Germany, Japan, and China. The Human Genome Project began in 1990 and was completed in 2003, two years ahead of schedule. It is estimated that only 1% of the 20,000 – 25,000 genes have been identified in their function. A second project is underway to determine the function and variants of the remaining 99%.
If you are struggling with weight loss, the genetic testing for weight management is for you. You don’t have to guess or experiment with what diet will work for you. The test is very reasonable in cost at $179, and comes with a detailed report of 20+ pages. Call us today to get started on a specific weight loss program designed for you.
GENETIC TESTING FOR NUTRITIONAL NEEDS
This testing analysis shows how the body uses vitamins and micronutrients. The testing identifies and individuals likely to have vitamin B dependent metabolism and reduced response to oxidative stress. Researchers have been able to link variations of B vitamin related
There are three other areas where genetic testing can provide invaluable information. The first is nutritional needs. Genetic testing can determine if an individual has an absorption, utilization, or metabolizing problem with Vitamins B, C, D, E, and more! A Vitamin B is involved in every metabolic process in the body. This information can be life-saving as some individuals will need to supplement certain B vitamins as much as 700% more than average to have normal function. The second additional area that genetic testing provides insight is in heart health. Heart disease accounts for 40% of all deaths in the United States. Certain variants will predispose an individual to greater risks. More importantly, the genetic testing provides the information on how not to express this variant. The study of the expression of genes is known as epigenetics. The third additional area that genetic testing shines is in bone health. There are three variants that increase an individual’s risk for developing osteoporosis; one involving interleukin, the second, estrogen and the third vitamin D. We will discuss more about each of these areas of genetic testing later.
All this information came about because of The Human Genome Project. The purpose of this project was to determine the human genome and to identify the genes it contains. This was an international endeavor initiated by the National Institute of Health and U.S. Department of Energy. Additional contributors included universities across the U. S and international partners in the U.K., France, Germany, Japan, and China. The Human Genome Project began in 1990 and was completed in 2003, two years ahead of schedule. It is estimated that only 1% of the 20,000 – 25,000 genes have been identified in their function. A second project is underway to determine the function and variants of the remaining 99%.
If you are struggling with weight loss, the genetic testing for weight management is for you. You don’t have to guess or experiment with what diet will work for you. The test is very reasonable in cost at $179, and comes with a detailed report of 20+ pages. Call us today to get started on a specific weight loss program designed for you.
GENETIC TESTING FOR NUTRITIONAL NEEDS
This testing analysis shows how the body uses vitamins and micronutrients. The testing identifies and individuals likely to have vitamin B dependent metabolism and reduced response to oxidative stress. Researchers have been able to link variations of B vitamin related
genes and how well the body uses B vitamins. These gene variants or polymorphisms are associated with increased risk for certain diseases, including cardiovascular disease. Analysis of variant genes affecting vitamins C, D, and E, and many other nutrients have been uncovered as well. There have been two genes related to vitamin B metabolism. 5-10-methyleneletrahldrofolate reductase gene (MTHFR) has a variant associated with less efficient activity of enzymes that depends on B vitamins for optimal function. Transcobalamin 2 gene (TCN2) contains a variant associated with the body’s need for vitamin B12 and how effectively it reaches the cells. If a person has one or more of these variants for these genes , they will have less effective utilization of B vitamins If the person tests positive for either the MTHFR or TCN2 variants, they will have less effective utilization of the B vitamins, requiring up to 400-700% more B6, B12, and folate for optimal function.
Genetic markers have been identified that are associated with the predisposition to having lower levels of certain key nutrients. Ensuring that you consume the right amount of vitamins and nutrients with your diet is part of an important health plan. The recommended daily allowance (RDA) for vitamins and nutrients are based on guidance from the Institute of Medicine of the National Academies are our minimal needs to survive, and not optimal, especially if you have one of these gene variants. This new information about what kind of gene marker a person has is important to know as it gives an indication on how much of a certain vitamin or nutrient a person really needs. The following is a list of nutrient/foods and the potential health and weight loss benefit of each associated gene(s).
| Nutrient/Food | Potential Health & Weight Loss Benefits | Associated Gene |
| Reversatrol | weight loss, decrease weight gain | SIRTI, PPARA, ER |
| Polyphenols(tea) | decrease weight gain | PPARG |
| CLA | fat burning, weight loss | PPARA, PPARG |
| Isoprenols | weight loss | PPARA, PPARG |
| Abetic Acid | weight loss | PPARG |
| Capsein (hot pepper) | weight loss, anti-inflammatory | PPARG |
| Phytol (chlorophyll) | weight loss | PPARA |
| Auroptene (citrus) | weight loss | PPARA, PPARG |
| Isohumulone (hops) | weight loss | PPARA, PPARG |
| Gugglesterone (gugle) | weight loss | Famerord X Factor |
| Soy/Genisten | weight loss | Estrogen, Androgen, Progesterone rec |
| Diosgenin | weight loss | Progesterone rec |
| Ginseng | weight loss | Estrogen receptors |
| Hyperforin | weight loss | Pregnone X Factor |
| Alpha-lipoic-acid | reduction of overeating | AMPK inhibitor |
| Anthocyanins (pigment) | overall health benefits | Adiopectin |
| Licorice LFA (polyphenols) | overall health benefits | Fatty Acid synthesis |
| Pomegrante extract | overall health benefits | B-oxidation, PPARA |
| Linoleic acid | overall health benefits | PPARA |
Vitamin B2 (riboflavin) is involved with two genes; favin mononucleotide (FMN) and favin adenine dinucleotide (FAD) which are both co-factors of several critical enzymes in electron transport chains and in the metabolism of carbohydrates, fats, and proteins. Individuals with the T/T genotype are more likely to have higher homocysteine levels, an inflammatory marker which is a risk factor for cardiovascular disease and stroke. Homocysteine levels are highest in T/T genotypes with low riboflavin levels .The good news is that riboflavin supplementation has been shown to reduce homocysteine levels in these individuals.
Vitamin B6 (pyridoxine) helps the body’s neurological system to function properly, promotes red blood cell health, and is involved with sugar metabolism. Individuals with C/C or C/T genotypes have lower B6 levels than those with T/T genotype. The normal recommendation for B6 is 1.3-1.7 mg/day. Those individuals with th C/C or C/T genotype will need significantly more B6 supplementation.
Vitamin B12 plays an important role in how the brain and nervous system functions, helps to keep red blood cells healthy, and is a critical component for the synthesis and regulation of DNA. Symptoms of B12 deficiency are broad and varied, but may include depression, difficulty multi-tasking, fatigue, weakness, bloating, neuropathy, numbness and tingling in the hands and feet, memory problems, an ADD in children. The recommended intake for adults is 2.4 mcg/day. Multiple genetic studies have identified the marker in gene FUT2 associated with lower levels of B2 in the blood, which may be due to reduced absorption of B12 in the gut. I have observed on several occasions where a patient had elevated B12 levels in the blood, but exhibited B12 deficiency symptoms. This gene variant would explain this type of occurrence. People with A/A genotypes tend to have normal levels of B12 if they “Stay Balanced” and maintain a healthy diet. People with B/B or A/G genotypes will have a tendency ti have lower B12 levels and will need supplementation with foods rich in B12 , especially after age 50, to avoid permanent neurological damage. These individual have normal B12 levels in the blood, but cannot get the B12 inside of the cell. These patients need B12 injections and/or sublingual B12 with liposome technology. The liposome technology is used in our clinic.
Folate-Folic acid plays a role in protein synthesis and DNA repair. Folate can lower homocysteine which is linked to cardiovascular disease and elevated levels of homocysteine. Diets rich in folate from dark green vegetables are associated with a reduced risk of cardiovascular disease. Folate is particularly important in early pregnancy as it helps prevent many birth defects. The recommended intake of folate for most adults is 400mcg/day. Pregnant women or those who are intending to become pregnant are advised to have 600mcg/day. If this is the amount necessary to prevent birth defects, then I suspect we need that and more for optimum function. A relatively common variant in the MTHFR gene at address C677T-rs1801133 is associated with lower folate and elevated homocysteine levels in the blood. These individuals with this variant need significantly more folate than average.
Vitamin A describes a number of related compounds including retinol, retinal, and retinoic acid. Vitamin A is critical for numerous functions in the body including healthy vision, immune system actions, bone growth, reproduction, and proper regulation of gene expression.
Vitamin C in severe deficiency ultimately leads to scurvy, a disease that causes a person to hemorrhage to death. This occurred several hundred years ago on long voyages until an English sea captain discovered that limes would stop the disease, hence the nickname “limies” for Englishman. Many ships carried potatoes, and these were fed to the crew daily, and there was enough vitamin C in the potato to prevent scurvy. Variations in vitamin C levels are associated with a wide variety of chronic complex diseases such as atherosclerosis, type 2 diabetes, and cancer. In the 1990’s, Linaus Pauling and Matthias Rath developed a patented nutriceutical that arrested and reversed plaquing. It contained both water and oil soluble vitamin C, B vitamins, and amino acids. The roles of vitamin c are as an anti0oxidant and with the synthesis of collagen and various hormones. After ingestion, vitamin C is transported across cell membranes via a transport protein, a gene called SLC23A1. A recent study found that an allele variant in SLC23A1 is associated with decreased levels of circulating vitamin C. Genotype A/A and A/G must have higher than average intake of vitamin C to have optimal function. Genotype G/G can maintain healthy levels by “Staying Balanced” and proper diet.
It makes perfect sense to have this testing done so that individuals will know where his/her deficiencies are and supplement accordingly. This testing explains why two different people can have polar opposite results eating the same diet. It also explains why some people need less supplementation than others. This testing allows an individual to have a customized diet and supplement program to optimize their health based on their unique needs through genotyping. Call today for more information and to schedule an appointment for genetic testing.
The test is easy to do, just rub the inside of each cheek with a brush that is provided for you. The test is very reasonable in cost, and provides you with invaluable information to protect your precious health. This service is provided through Hoffman Clinic for Optimal Health.Call today at (813) 985-1322.
Kelly Miller, DC NMD FASA FBAARM CFDMP*, is a physician for Hoffman Clinic for Optimal Health.
*There is currently no licensure for Naturopathic physicians (NMD) in the state of Florida and the Florida Board of Chiropractic Medicine does not currently recognize the credentialing of the Fellowship from the Brazil-American Academy for Aging and Regenerative Medicine (FBAARM), or the Certification in Functional Diagnostic Medicine (CFDMP) from Functional Medicine University.